I'd say, it depends.
Let's say, you're in a dangerous cave. You certainly want to capture that sense of anxiety in your score. Maybe some dark atmospheric pad with a few awkward noises. You don't want your players to whistle along here.
On the other hand, when portraiting a strong and important character, faction or place, you want to use a strong, recognizable theme. For example, if in the dungeon from above, you start fiddling in the theme of the big bad boss, players will subconsciously sense what's coming without knowingly recognizing the theme, necessarily.
Of course, it all depends on each individual game. So, if you, say, have a lounge before your online matches, you probably want a theme that makes players feel comfortable and ready for a fight while not poking their nerves too much if gets repetitive.
Your question doesn't have a simple either/or answer. So I hope, I was able to help, anyway.