Can I ask a potentially dumb question? If you buy super-high-res monitors and then have to scale everything in order to see it, what exactly is the benefit? I have a couple of 21" monitors running 1280x1024 which is about 75dpi. If I wanted more screen space and got 2 28" displays then 1600x1200 would give a similar dpi and at the distance I sit I don't get offended by the pixel size. If you're having to "fix" the problem of the pixels being so small, what are the benefits?
Most people would seem to prefer smaller pixels than you seem to care for, but even if you wanted the same effective point-size for your text, a higher resolution still makes images and text sharper, and many people find the text to be more comfortable to read as a result.