I realize that this is a completely terrible and reckless idea in terms of career gambling, but would people want a story with a completely new plot, setting, tropes, character personalities, and overall concepts?
It seems to me that every story-driven entertainment ever has been seeking to create "the next big thing;" trying to start a new trend or exploring never previously conceived topics, like it's the "White Whale" of story writing. I see that lots of times it works, most of the time it doesn't, but just seeing this everywhere and all the time, gets me thinking...
I know, especially firsthand, that people usually like some form of familiarity and relatability in their stories to balance it out, but could it be possible to write something well-received without that? Could something truly "New" completely sweep the market, or just be a land-filler?