1. As soon as you "leave the couch" (replace with "leave the office chair" for PC gaming), you get into the areas of "tiring activities". Yes, you can run for hours... if you are physically fit and really ready to put up with all the sweat and time investment to get physically fit. Yes, as soon as you get into "nervegear territory" and no longer need to move your body - you shortcut the brain to see a "different reality" and sever the connection to your physical body - you are no longer really in need of physical fitness... but you can bet that the expierience would be REALLY mentally tiring.
You also will start to encounter new phenomenas that would make you probably not want to live through realistic shooter expieriences or horrorgames in a VR game that is indistinguishable from reality... SOA alludes to it (if it was a better series, it would do way more than just show it in short burst at the beginning to then go back to a boring story about teenage love and a mary sue character).
You would probably get into the area of PTSD being induced by your horrific VR war scenarios, or psychosis triggered by to real horror games. Really, for most soldiers its not a question IF they develop a posttraumatic stress disorder... the question is how long it takes until they can no longer function in a warzone... or, even worse, normal society.
Yes, there are people that can avoid that. They are mostly psychopaths. You are born with it. And you probably will end up in jail or dead, if you don't hide it well (and become rich and famous thanks to our current society being the ideal playground for psychopaths that can play by the law).
You probably can make all kind of interesting and cool alternative reality expieriences... they will be quite boring after a while, and resemble real life pretty close (you know, the game with awesome graphics but really crappy content)... unless our world has gone to shit until then, the question remains "why even bother?"....
You can probably make some high adrenaline scenarios resembling current action games that are really exciting and immersive. But you only ever want to consume it in very short bursts, because they might be physically taxing, and they almost certainly will be mentally distressing.
2. I am not getting into the "WHY???" when it comes to your quite out there numbers of NPCs and stuff to simulate... lets just say when it is hard to create HUNDREDS of NPCs that are not an indistinguishable mess, billions of NPCs randomly generated would be just pointlessly same-ish. Might as well create one thousand and copy and paste them to the world, you wouldn't be able to tell the difference. The human mind, at its best, can keep track of maybe 100 other human beings on a personal level. Everyone beyond that is just part of a number in a statistics. By the time you meet your 101st NPC for example you will not care anymore, or you start to forget about your first NPC (or probably your tenth, the first might staying in your mind longer) you met in the game.
But now I do get into the why... so lets get back on track.
No, Quantum computing will probably not help. Unless you want to "simulate" your billion of NPCs in a very simple way. Name, age, height, thats it. As soon as they should actually have a simulated "life" of any real depth, you will need an array of Processors beyond what any supercomputer in the world has, even with some shiny new quantum computing tech that REALLY delivers on the hyperbole (and as usual, the reality will never live up to the hype). You probably waste billions of dollars on the hardware and hefty sum in needed energy each month just to run a coarse simulation for a billion boring virtual lifes. Again, probably not worth it beyond the "for the heck of it" science e-peen.
Getting back to the "WHY???" I wanted to avoid: As fun as pokemon might be on a smaller scale, there are only so many randomly generated pokemons you can create before you have seen it all... there are just so many NPCs you can cram into a VR World before they start blend together into a boring mass of "meh!". I think the draw of the current AR pokemon craze is the AR part. The fact that pokemons are hidden in the real world (and the thrill of being in danger of falling down the cliffside with permadeath). For one, it is questionable what a simulated world to replace the already highdef realworld would really add to that game, when you can just omit crunching a whole lot of data by using what is already there. Especially with a game like pokemon, that does not rely on highdef graphics to sell itself, thus the AR discrepancy between simulated pokemon and real world is not really that much of a problem. Expecially with a game that is a collectathlon with most of the "garnish" of other games removed (yes, you can have monster fights with your collectable items... yes there is an actual game world to collect the items in. Compared to other games that layer IMO is pretty thin).
As much as a SOA like Virtual world sound awesome, as much as you could build really fantastic and exciting worlds... there is only so much the human brain can take, and what is awesome and exciting in short burst for 80 hours becomes boring and dreary once you hit the 1000 hour mark. Yes, there are the WoW addicts... but these people are wasting way too much time in a virtual world for a reason... mostly they have trouble with the real world (maybe social anxiety problems and stuff like this), or other addiction problems. Are they happy in their alternate reality.... hell, yes, I guess they have to get something out of it. I would be the last one to judge people for wasting all their free time in a virtual reality... as long as they still work for a living, that is.
But the general mass audience will probably never stick around for that long in a world that starts to resemble the real world as soon as the novelty of the fantasy / sci-fi setting wears off, and the handcrafted content is used up... procgen random quests and worlds and items will start to bore them quickly. As long as your real world situation is not really shitty for one reason or another, of course. If our realworld turns into a dystopia, the VR world might be the better alternative.
The really interesting case study is rather Second life than AR Pokemon, or Sci-Fi stuff like SOA. As soon as the virtual world can be used for more than entertainment, it might be able to tie people to the virtual reality for longer. If you can work in VR, socialize in VR and, yes, play for a short time in VR, people might actually start "living" in the VR world the same way some addicts do nowadays in some MMO games.
Will this be for the better or worse of society? Will it be anywhere near as fantastic as the hype makes you believe, or in the end just a pedestrian as most other new technology when it finally arrives? Who knows. But I think a little bit moderation of expectation instead of overblown hype is in order at this stage.