A lot of studios are a Work-For-Hire business model, where they don't really get to decide at all what they're going to make. Instead, you find publishers/IP-owners who need studio to make a game for them, and then you create a pitch to try and secure that work (which may involve making a GDD/TDD, concept art, a budget, and even a small prototype)... and then hopefully your studio is selected to make the game.
At self-funded studios, it will usually be an executive/director who makes the choice of what game to make next -- CEO (managing director in real English) or creative director, etc... Hopefully though, the design and concepting teams would have a lot of input in the process, and even flesh out a few different game designs before one is chosen.
Might I add that successful vendors still have a strong say regarding which opportunities they will pursue?
I've been places where they had to pitch evertime and others where they passed on a lot of things.
In both cases, the call came from the CEO or president who represented the AC's interests.