Exactly what kind of malware do you expect to pick up from Gamedev?
If you are doing things legitimately it should be relatively safe - game developers generally just want to get their games seen and wouldnt risk their reputation by sending malware instead, and if you get your development tools from legitimate sites there is no real risk of getting a virus, unless you are going to get it from warez sites (ugh, ugh, ugh i feel dirty for mentioning it!).
Follow sensible security practices as you would for any other usage of the computer - don't execute software from untrusted sources or software you did not explicitly go looking for, and don't just follow instructions of strangers blindly - this does go for tutorial code too - if you arent sure, read it and understand it before you run it.
Take regular backups. Test those backups. If neccessary, use antivirus software. These are common sense pieces of advice for any usage of a computer in the modern age.
Have fun!
Quick Edit: if you're really concerned, install an OS to a seperate disk, and yank out the disk you want to protect before booting your sacrificial OS... There is no malware that can move to a disk that isnt physically connected.