I believe that the current hardware technology has yet to be fully exploited by lower level coding. As covered here, memory utilization has yet to be connected most effectively with processing.
Some questions for areas of progress:
1) Binary - Where can improvement be made to help the average game developer?
2) Virtual transistors - Why can't coding emulate the digital transistor better than it does?
3) 3D light processors (3 dimensions instead of the 2 dimensional chip and using light in the processing in conjunction with electricity, such as micro-LEDs)
4) What is the probability that several immerging different technologies compete for many years and each will be promoted by competing companies?
5) Related to the previous question: Are we going to see more niche deployment for small and middle size developers and cross-platform left mostly to the biggest game developers?
6) Will performance leap enable more inefficient coding to be competitive?
7) Could performance leap stay beyond the cost range of most consumers and developers?