I use Windows 7 for my desktop (mainly because videogames) and Debian for my netbook which I use for most of my uni work assignments (except that one time I had to install SQL Server Express, which is Windows only and uses a ton of ram) even used it for my OOP course exams (and almost wrecked the professor's external hard drive once ).
I found linux a pretty good choice for my netbook since Windows 7 was too much of a performance hog for my poor single core Atom and installing an "ancient" OS like Windows XP wasn't an option.
So with my LXDE Debian install I got the possibility of not missing 10 years in OS development and get good performance out of it (modern OS that uses 90Mb of RAM, how cool is that?).
Though to be said, using a relative "new" desktop environment wasn't such a good idea, I didn't had a working battery monitor for a good while and I have been using WiFi via the console (ifup/ifdown and config files) since I got pissed off by the network managers available (either you install 80% of Gnome to get the Gnome Network Manager or you're on your own).
Probably I will switch to a recent build of Gnome Debian (that has the Gnome 2 look, which performs quite well actually and has all the configuration utilities you could ask for).
I don't use Wine though, I think it defeats the purpose when there are available alternatives. I've been using OpenOffice on my Windows desktop for a few years actually, and with the Debian I started to use Gimp more. I really like the package managers and the tons of programs that are available.
Using LXDE was a good learning experience though, got to use the console often which is pretty fun mostly (find/locate is friggin' fast!). I'd like to know a lot more about Linux since knowledge is the thing that keeps you from doing cool stuff with it.
Probably the only thing that is keeping me from going Linux 24/7 is games. If the game industry gave me native Linux games, I'd probably switch to Linux completely.