No real clue, but one aspect that I would love to see adopted by more software is one found in some industrial and military equipment I've used where there was no quick "Click here once to do whatever this controls" mechanic. Instead there were sliders. In order to select a given option you had to click and drag across the 'button' zone, or make a very deliberate series of key strokes while holding a set key down.
For instance you would have a quit with out saving option. To do so you click and hold on the far right side of the popup window for that 'button' zone, drag to the left. The message changes to "Quitting WITHOUT saving, data will not be saved". Releasing the mouse then cancels the order, but dragging it back to the right confirms it. It doesn't even require dual axis accuracy for it, just capture the curser as you slide it back and forth and lock it on the slider plane.
It takes fractionally longer to do, but gives you multiple point warnings in a far smoother interface. It isn't brining up new popups that you then have to then focus on to bring the mouse directly to and click accurately.