Bad comparison. Most of the $2.5 billion is development costs and the very expensive hardware (MSL was a one-off scientific instrument, not a rugged, mass-produced industrial machine) that's actually being landed. The actual launch costs are a fraction of that $2.5 billion. Furthermore, MSL was designed and built under the design constraint of a single launch on an Atlas V. Those kinds of mass constraints tend to drive costs up. Any Mars industrial hardware would be lofted in multiple launches, possibly on reusable launchers en masse if SpaceX succeeds with the reusable Falcon 9.
So what would be the development costs for the equipment suitable for a Mars colony? It most likely wouldn't be rugged, mass-produced machinery either, since such machinery would certainly be engineered for Earth conditions, and not the conditions of Mars. Anything that goes to Mars is likely going to require rigorous development and testing before it is allowed on the mission, and since it would literally mean life or death for the colonists (unlike the science equipment on the rover) I'd warrant the testing standards would need to be even more rigorous.
You're not talking about another rover launch, or even a simple there-and-back-again manned mission. You're talking about a colony. How much do you think it'll cost?
I have no idea, which is why I'm not immediately jumping to the conclusion of ruling out the possibility of this happening.
You're talking about hundreds of thousands or even millions of kg of mass to be delivered to Mars.
One hundred thousand kg is one hundred tonnes. One Saturn V launch to low Earth orbit (not trans-Martian injection) was about that, so at least getting it into space isn't all that bad. Now, once it's in LEO you've still got to get it on a Mars trajectory and land it, but again, you don't have to launch it all at once. You can send it in chunks. Supposing you could land 25 tonnes in your lander (mass unspecified) - that's about the payload of a Space Shuttle back in the day - you've got to have 4 landings per 100 metric tonnes. If you only flew this cargo spacecraft at a rate of 4 times per year, you could land 1 million kg in a decade.
You're kind of making my point for me, here. 4 flights a year over a decade to land 1 million kg. That sounds like a supply line, not a self-sufficient colony. Granted, that's a shaky argument (what, exactly, is the timeframe for establishing a self-sufficient colony?) but still, it means that any investors looking at this from a for-profit standpoint will need to look at
very long timeframes for their return; ie, decades before the colony is up and running, even more decades before it starts to generate a profit. Certainly doable if companies are far-sighted enough, but still pretty unlikely.
This isn't sounding all that bad, actually.
Of course, your lander probably won't be able to handle 25 tonnes, at least on the early models, but even at half that (12.5 tonnes - a bit less than the heaviest ISS module), it's still 8 flights a year to get 100 tonnes on the surface of Mars every year. Given sufficient infrastructure Earth-side, that can (probably) be done. Even better, when you take into account the fact that each Mars lander of that size is likely to require at least two launches from Earth, you're getting to a flight rate that could justify reusable launch vehicles. So now you've got an excuse to get a reusable launch vehicle, and possibly bring down costs for everybody else who uses it (due to, again, economies of scale).
Given Mars's gravity, you could probably construct a space elevator (more feasibly than on Earth, at least) and reduce lander costs at some point in the project. I think an orbital colony to start would be the best bet.
Now, don't get me wrong here. I might sound like a cynical bastard, and I might not think that this really has any significant likelihood of success. I honestly believe that the free fossil-fuel ride is going to run out long before we short-sighted humans come up with good long-term solutions to the energy problem. In a way, fossil fuels have inspired a sort of species-wide delusion of grandeur; all this abundant free energy and the mad rush of "innovation" it inspired has us thinking that the sky is the limit and anything is possible if we just throw enough good, old-fashioned human ingenuity at it. The truth, though, seems to me to be a bit more depressing: once the easy energy runs out, we are left with good, old fashioned energy starvation and overall contraction in growth, with more and more of the dwindling resources required for mere survival of a slowly starving population, rather than extremely ambitious ventures to Mars.
But just because I have this grim view of things, doesn't mean I don't want them to try. If L.Spiro manages to spend the rest of his/her life on Mars, I will be overjoyed. I honestly want nothing more than for you to come back in thirty years (I'll prolly still be posting on gd.net then, if I don't die of my various vices first) and say "in your face, you cynical faithless bastard." Please do so, if such is warranted.
I'm just not really holding my breath.