http://www.airshipzprize.org/
Being worked on now. Probably not cost effective for US but definitely in China, Canada, and Latin America where the infrastructure isn't as defined.
In South America in general it would be great. Planes suck over rain forest because there is crazy bad turbulence. Not necessarily unsafe, but definitely unsettling. I almost pooped myself flying to iguazu. Landing at an airport the size of a football field surrounded by large trees didn't put me more at ease either.